Gabapentin enacarbil
CAS No. 478296-72-9
Gabapentin enacarbil ( XP-13512 )
产品货号. M26692 CAS No. 478296-72-9
Gabapentin enacarbil is a prodrug for the anticonvulsant and analgesic drug gabapentin.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1458 | 有现货 |
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10MG | ¥2401 | 有现货 |
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25MG | ¥3920 | 有现货 |
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50MG | ¥5875 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Gabapentin enacarbil
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Gabapentin enacarbil is a prodrug for the anticonvulsant and analgesic drug gabapentin.
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产品描述Gabapentin enacarbil is a prodrug for the anticonvulsant and analgesic drug gabapentin. Gabapentin enacarbil provides sustained dose-proportional exposure to gabapentin and predictable bioavailability. (In Vitro):Gabapentin enacarbil demonstrated active apical to basolateral transport across Caco-2 cell monolayers and pH-dependent passive permeability across artificial membranes. XP13512 inhibited uptake of (14)C-lactate by human embryonic kidney cells expressing monocarboxylate transporter type-1, and direct uptake of prodrug by these cells was confirmed using liquid chromatography-tandem mass spectrometry. XP13512 inhibited uptake of (3)H-biotin into Chinese hamster ovary cells overexpressing human sodium-dependent multivitamin transporter (SMVT) . (In Vivo):In 4 studies of healthy volunteers (136 subjects total), the pharmacokinetics of Gabapentin enacarbil immediate- and extended-release formulations were compared with those of oral gabapentin. Gabapentin enacarbil immediate-release (up to 2800 mg single dose and 2100 mg twice daily) was well absorbed (>68%, based on urinary recovery of gabapentin), converted rapidly to gabapentin, and provided dose-proportional exposure, whereas absorption of oral gabapentin declined with increasing doses to <27% at 1200 mg. Compared with 600 mg gabapentin, an equimolar Gabapentin enacarbil extended-release dose provided extended gabapentin exposure (time to maximum concentration, 8.4 vs 2.7 hours) and superior bioavailability (74.5% vs 36.6%) .
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同义词XP-13512
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number478296-72-9
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分子量329.4
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分子式C16H27NO6
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)C(=O)OC(C)OC(=O)NCC1(CC(O)=O)CCCCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lingxiao Zhang, et al. Synthetic method of 3',5' -dichloro-2, 2, 2-trifluoro acetophenone derivative. CN113024390A
产品手册
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